Linfohistiocitosis hemofagocitica asociado a fiebre enterica. Reporte de caso
Hemophagocytic lymphohistiocytosis associated with enteric fever. Case report
DOI:
https://doi.org/10.56712/latam.v7i1.5436Palabras clave:
fiebre tifoidea, fiebre entérica, linfohistiocitosis hemofagocíticaResumen
La linfohistiocitosis hemofagocítica (HLH) es un síndrome hiperinflamatorio potencialmente mortal que puede presentarse como una complicación secundaria de infecciones sistémicas.Describir un caso de HLH secundaria a fiebre entérica en un paciente pediátrico y resaltar la importancia del diagnóstico y tratamiento oportunos.Se presenta un paciente pediátrico con fiebre persistente y síntomas gastrointestinales, en quien se confirmó infección por Salmonella spp. A pesar del tratamiento antibiótico adecuado, evolucionó con deterioro clínico progresivo y cumplió criterios diagnósticos de HLH.La HLH debe considerarse en pacientes con infecciones invasivas y evolución clínica desfavorable, especialmente en regiones endémicas, para permitir un diagnóstico precoz y prevenir complicaciones graves.
Descargas
Citas
Chang, C. Y., Rajappan, M., Zaid, M., & Ong, E. L. (2020). Dengue complicated with hemophagocytic lymphohistiocytosis: Report of two cases and bone marrow findings. Clinical Case Reports, 8, 3427–3431. https://doi.org/10.1002/ccr3.3422
Cruz Espinoza, L. M., McCreedy, E., Holm, M., et al. (2019). Incidence of typhoid fever complications and their relation to disease duration before hospitalization: A systematic review and meta-analysis. Clinical Infectious Diseases, 69, 0–48. https://doi.org/10.1093/cid/ciz477
George, N., Sethi, P., Nischal, N., Kumar, A., Siripurapu, G., Wig, N., & Vyas, S. (2018). A catastrophic presentation of enteric fever with secondary hemophagocytic lymphohistiocytosis. Journal of the Association of Physicians of India, 66, 11–12.
Giang, H. T. N., Banno, K., Minh, L. H. N., et al. (2018). Dengue hemophagocytic syndrome: A systematic review and meta-analysis on epidemiology, clinical signs, outcomes, and risk factors. Reviews in Medical Virology, 28(6), e2005. https://doi.org/10.1002/rmv.2005
Hackett, L. W. (1943). Spleen measurement in malaria. Revista Peruana de Medicina Experimental y Salud Pública, 2(4).
Henter, J. I., Samuelsson-Horne, A., Aricò, M., et al. (2002). Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation. Blood, 100, 2367–2373. https://doi.org/10.1182/blood-2002-01-0172
Janka, G. E., & Lehmberg, K. (2013). Hemophagocytic lymphohistiocytosis: Pathogenesis and treatment. Hematology: American Society of Hematology Education Program, 2013, 605–611. https://doi.org/10.1182/asheducation-2013.1.605
Jasmine, Y. S., Lee, S. L., & Kan, F. K. (2017). Infection-associated haemophagocytic syndrome in severe dengue infection: A case series in a district hospital. Medical Journal of Malaysia, 72(1), 62–64.
Kim, Y. R., & Kim, D. Y. (2021). Current status of diagnosis and treatment of hemophagocytic lymphohistiocytosis in adults. Blood Research, 56, 25. https://doi.org/10.5045/br.2021.2020323
Koumadoraki, E., Madouros, N., Sharif, S., Saleem, A., Jarvis, S., & Khan, S. (2022). Hemophagocytic lymphohistiocytosis and infection: A literature review. Cureus, 14, e22411. https://doi.org/10.7759/cureus.22411
Morimoto, A., Nakazawa, Y., & Ishii, E. (2016). Hemophagocytic lymphohistiocytosis: Pathogenesis, diagnosis, and management. Pediatrics International, 58, 817–825. https://doi.org/10.1111/ped.13064
Non, L. R., Patel, R., Esmaeeli, A., & Despotovic, V. (2015). Typhoid fever is complicated by hemophagocytic lymphohistiocytosis and rhabdomyolysis. American Journal of Tropical Medicine and Hygiene, 93, 1068–1069. https://doi.org/10.4269/ajtmh.15-0385
Obayo, A., Sharma, K., Mithi, C., Riyat, M., & Mwirigi, A. (2020). Secondary hemophagocytic lymphohistiocytosis in adults. EJem, 1, 567–575. https://doi.org/10.1002/jha2.113
Rajani, H. S., Narayanappa, D., Prashanth, S. N., Batra, A., & Godi, A. (2023). Enteric fever complicated by hemophagocytic lymphohistiocytosis: An unusual case report. Journal of Pediatric and Neonatal Individualized Medicine, 12(1), e120116.
Ray, U., Dutta, S., Bandyopadhyay, S., & Mondal, S. (2019). Infections and hemophagocytic lymphohistiocytosis: Experience from a tertiary care centre. Journal of the Association of Physicians of India, 67, 54–57.
Ray, U., Dutta, S., Bandyopadhyay, S., & Mondal, S. (2020). An uncommon presentation of a common tropical infection. Indian Journal of Pathology and Microbiology, 63, 161–163. https://doi.org/10.4103/IJPM.IJPM_306_18
Rosée, P., Horne, A., Hines, M., et al. (2019). Recomendations for the management of hemophagocytic lymphohistiocytosis in adults. Blood, 133, 2465–2477. https://doi.org/10.1182/blood.2018894618
Sánchez-Moreno, P., Olbrich, P., Falcón-Neyra, L., Lucena, J. M., Aznar, J., & Neth, O. (2019). Typhoid fever causing hemophagocytic lymphohistiocytosis in a non-endemic country: First case report and review of the literature. Enfermedades Infecciosas y Microbiología Clínica (English Edition), 37, 112–116. https://doi.org/10.1016/j.eimc.2018.04.011
Thriemer, K., Ley, B., Ame, S. S., et al. (2012). Clinical and epidemiological features of typhoid fever in Pemba, Zanzibar: Evaluation of WHO case definitions. PLoS ONE, 7, e51823. https://doi.org/10.1371/journal.pone.0051823
Zhang, Z., Liu, J., Wang, J., & Wang, Y. (2021). Hemophagocytic lymphohistiocytosis associated with Klebsiella pneumoniae infection: A case report. Frontiers in Immunology, 12, 684805. https://doi.org/10.3389/fimmu.2021.684805
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2026 Juan Carlos Ferreira
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
