Consumo de creatina y cognición: una revisión bibliográfica

Creatine intake and cognition: a literature review

Autores/as

  • Mauricio Núñez Núnez Universidad Técnica de Ambato, Facultad de Ciencias de la Salud / Grupo de Investigación Nutrigenx https://orcid.org/0000-0002-9692-1642
  • Andrea del Rocío Mejía Rubio Universidad Técnica de Ambato, Facultad de Ciencias de la Salud / Grupo de Investigación Nutrigenx https://orcid.org/0000-0001-9371-9636
  • Ana Gabriela Pacha Jara Universidad Técnica de Ambato, Facultad de Ciencias de la Salud
  • Kattyta Patricia Hidalgo Morales Universidad Técnica de Ambato, Facultad de Ciencias de la Salud / Grupo de Investigación Nutrigenx

DOI:

https://doi.org/10.56712/latam.v4i5.1306

Palabras clave:

atp, cognición, creatina, procesamiento cognitivo

Resumen

La creatina es un compuesto químico natural presente en pequeñas cantidades en el cuerpo y determinados alimentos y suplementos, cuya principal función es suministrar energía inmediata a los tejidos que requieren de mayor demanda energética como son los músculos y el cerebro que se encarga del procesamiento cognitivo y desarrollo de funciones como la memoria, atención, gnosias, praxias y funcionamiento ejecutivo. Determinar la efectividad del consumo de creatina sobre el funcionamiento cognitivo. Se ha realizado una revisión bibliográfica que incluye 10 artículos científicos publicados en Scopus, Web of Science, Pubmed y Taylor and Francis. La suplementación con creatina ayuda en el rendimiento de algunas de las tareas cognitivas evaluadas en cada estudio; de las siete investigaciones que analizan cambios en la puntuación de memoria, 2 refieren cambios estadísticamente significativos. Sobre los resultados de tiempos de reacción, vigilancia y atención, 2 de los 6 estudios refieren cambios a favor del consumo de creatina. En relación con el funcionamiento ejecutivo, sólo un estudio de los 5 refieren beneficios de la suplementación. En cuanto a la cognición global, 1 de los 2 estudios reporta cambios de puntuación a favor del grupo de intervención. La suplementación con creatina no reporta efectos positivos en todas las funciones cognitivas estudiadas, se trata de un compuesto que no reporta efectos secundarios nocivos, y que hoy en día es seguro y fácil de consumir.

Descargas

Los datos de descargas todavía no están disponibles.

Biografía del autor/a

Mauricio Núñez Núnez, Universidad Técnica de Ambato, Facultad de Ciencias de la Salud / Grupo de Investigación Nutrigenx

Andrea del Rocío Mejía Rubio, Universidad Técnica de Ambato, Facultad de Ciencias de la Salud / Grupo de Investigación Nutrigenx

Ana Gabriela Pacha Jara, Universidad Técnica de Ambato, Facultad de Ciencias de la Salud

Kattyta Patricia Hidalgo Morales, Universidad Técnica de Ambato, Facultad de Ciencias de la Salud / Grupo de Investigación Nutrigenx

Citas

Allen, P. J. (2012). Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value? Neuroscience & Biobehavioral Reviews, 36(5), 1442-1462. https://doi.org/10.1016/j.neubiorev.2012.03.005

Alves, C. R. R., Merege Filho, C. A. A., Benatti, F. B., Brucki, S., Pereira, R. M. R., De Sá Pinto, A. L., Lima, F. R., Roschel, H., & Gualano, B. (2013). Creatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study. PLoS ONE, 8(10), e76301. https://doi.org/10.1371/journal.pone.0076301

Alves, C. R. R., Santiago, B. M., Lima, F. R., Otaduy, M. C. G., Calich, A. L., Tritto, A. C. C., De Sá Pinto, A. L., Roschel, H., Leite, C. C., Benatti, F. B., Bonfá, E., & Gualano, B. (2013). Creatine Supplementation in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Trial: Efficacy and Safety of Creatine Supplementation in FM Patients. Arthritis Care & Research, 65(9), 1449-1459. https://doi.org/10.1002/acr.22020

Andres, R. H., Ducray, A. D., Schlattner, U., Wallimann, T., & Widmer, H. R. (2008). Functions and effects of creatine in the central nervous system. Brain Research Bulletin, 76(4), 329-343. https://doi.org/10.1016/j.brainresbull.2008.02.035

Balestrino, M., & Adriano, E. (2019). Beyond sports: Efficacy and safety of creatine supplementation in pathological or paraphysiological conditions of brain and muscle. Medicinal Research Reviews, 39(6), 2427-2459. https://doi.org/10.1002/med.21590

Benton, D., & Donohoe, R. (2011). The influence of creatine supplementation on the cognitive functioning of vegetarians and omnivores. British Journal of Nutrition, 105(7), 1100-1105. https://doi.org/10.1017/S0007114510004733

Burke, D. G., Candow, D. G., Chilibeck, P. D., MacNeil, L. G., Roy, B. D., Tarnopolsky, M. A., & Ziegenfuss, T. (2008). Effect of Creatine Supplementation and Resistance-Exercise Training on Muscle Insulin-Like Growth Factor in Young Adults. International Journal of Sport Nutrition and Exercise Metabolism, 18(4), 389-398. https://doi.org/10.1123/ijsnem.18.4.389

Candow, D. G., Forbes, S. C., Chilibeck, P. D., Cornish, S. M., Antonio, J., & Kreider, R. B. (2019). Variables Influencing the Effectiveness of Creatine Supplementation as a Therapeutic Intervention for Sarcopenia. Frontiers in Nutrition, 6. https://www.frontiersin.org/articles/10.3389/fnut.2019.00124

Casey, A., & Greenhaff, P. L. (2000). Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance? The American Journal of Clinical Nutrition, 72(2 Suppl), 607S-17S. https://doi.org/10.1093/ajcn/72.2.607S

Cutsem, J., Roelands, B., Pluym, B., Tassignon, B., Verschueren, J. O., DE Pauw, K., & Meeusen, R. (2020). Can Creatine Combat the Mental Fatigue-associated Decrease in Visuomotor Skills. Medicine and Science in Sports and Exercise, 52(1), 120-130. https://doi.org/10.1249/mss.0000000000002122

Deminice, R., Rosa, F. T., Franco, G. S., Jordao, A. A., & De Freitas, E. C. (2013). Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans. Nutrition, 29(9), 1127-1132. https://doi.org/10.1016/j.nut.2013.03.003

Directo, D., Wong, M. W. H., Elam, M. L., Falcone, P., Osmond, A., & Jo, E. (2019). The Effects of a Multi-Ingredient Performance Supplement Combined with Resistance Training on Exercise Volume, Muscular Strength, and Body Composition. Sports, 7(6), 152. https://doi.org/10.3390/sports7060152

Dolan, E., Artioli, G. G., Pereira, R. M. R., & Gualano, B. (2019). Muscular Atrophy and Sarcopenia in the Elderly: Is There a Role for Creatine Supplementation? Biomolecules, 9(11), 642. https://doi.org/10.3390/biom9110642

Dolan, E., Gualano, B., & Rawson, E. S. (2019a). Beyond muscle: The effects of creatine supplementation on brain creatine, cognitive processing, and traumatic brain injury. European Journal of Sport Science, 19(1), 1-14. Scopus. https://doi.org/10.1080/17461391.2018.1500644

Dolan, E., Gualano, B., & Rawson, E. S. (2019b). Beyond muscle: The effects of creatine supplementation on brain creatine, cognitive processing, and traumatic brain injury. European Journal of Sport Science, 19(1), 1-14. https://doi.org/10.1080/17461391.2018.1500644

Gualano, B., Rawson, E. S., Candow, D. G., & Chilibeck, P. D. (2016). Creatine supplementation in the aging population: Effects on skeletal muscle, bone and brain. Amino Acids, 48(8), 1793-1805. https://doi.org/10.1007/s00726-016-2239-7

Hall, M., Manetta, E., & Tupper, K. (2021). Creatine supplementation: An update. Current Sports Medicine Reports, 20(7), 338-344. Scopus. https://doi.org/10.1249/JSR.0000000000000863

Joncquel-Chevalier Curt, M., Voicu, P.-M., Fontaine, M., Dessein, A.-F., Porchet, N., Mention-Mulliez, K., Dobbelaere, D., Soto-Ares, G., Cheillan, D., & Vamecq, J. (2015). Creatine biosynthesis and transport in health and disease. Biochimie, 119, 146-165. https://doi.org/10.1016/j.biochi.2015.10.022

Kreider, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., Candow, D. G., Kleiner, S. M., Almada, A. L., & Lopez, H. L. (2017). International Society of Sports Nutrition position stand: Safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14, 18. https://doi.org/10.1186/s12970-017-0173-z

Kreider, R. B., & Stout, J. R. (2021). Creatine in health and disease. Nutrients, 13(2), 1-28. Scopus. https://doi.org/10.3390/nu13020447

Lieberman, H. R., Tharion, W. J., Shukitt-Hale, B., Speckman, K. L., & Tulley, R. (2002). Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land. Psychopharmacology, 164(3), 250-261. https://doi.org/10.1007/s00213-002-1217-9

McMorris, T., Harris, R. C., Swain, J., Corbett, J., Collard, K., Dyson, R. J., Dye, L., Hodgson, C., & Draper, N. (2006). Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol. Psychopharmacology, 185(1), 93-103. https://doi.org/10.1007/s00213-005-0269-z

Merege-Filho, C. A. A., Otaduy, M. C. G., de Sá-Pinto, A. L., de Oliveira, M. O., de Souza Gonçalves, L., Hayashi, A. P. T., Roschel, H., Pereira, R. M. R., Silva, C. A., Brucki, S. M. D., da Costa Leite, C., & Gualano, B. (2017). Does brain creatine content rely on exogenous creatine in healthy youth? A proof-of-principle study. Applied Physiology, Nutrition, and Metabolism, 42(2), 128-134. https://doi.org/10.1139/apnm-2016-0406

Persky, A. M., & Rawson, E. S. (2007). Safety of creatine supplementation. Sub-Cellular Biochemistry, 46, 275-289. https://doi.org/10.1007/978-1-4020-6486-9_14

Pomportes, L., Davranche, K., Hays, A., & Brisswalter, J. (2015). Effect of a creatine-guarana complex on muscular power and cognitive performance in high-level athletes. SCIENCE & SPORTS, 30(4), 188-195. https://doi.org/10.1016/j.scispo.2015.04.002

Rawson, E. S., Lieberman, H. R., Walsh, T. M., Zuber, S. M., Harhart, J. M., & Matthews, T. C. (2008). Creatine supplementation does not improve cognitive function in young adults. Physiology & Behavior, 95(1-2), 130-134. https://doi.org/10.1016/j.physbeh.2008.05.009

Rodrigues Alves, C. R., Abujabra Merege Filho, C. A., Benatti, F. B., Brucki, S., Pereira, R. M. R., de Sa Pinto, A. L., Lima, F. R., Roschel, H., & Gualano, B. (2013). Creatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study. PLoS ONE, 8(10), e76301. https://doi.org/10.1371/journal.pone.0076301

Sandkühler, J. F., Kersting, X., Faust, A., Königs, E. K., Altman, G., Ettinger, U., Lux, S., Philipsen, A., Müller, H., & Brauner, J. (2023). The effects of creatine supplementation on cognitive performance—A randomised controlled study (p. 2023.04.05.23288194). medRxiv. https://doi.org/10.1101/2023.04.05.23288194

Smith, J. C., & Hill, D. W. (1991). Contribution of energy systems during a Wingate power test. British Journal of Sports Medicine, 25(4), 196-199. https://doi.org/10.1136/bjsm.25.4.196

Smolarek, A. C., McAnulty, S. R., Ferreira, L. H., Cordeiro, G. R., Alessi, A., Rebesco, D. B., Honorato, I. C., Laat, E. F., Mascarenhas, L. P., & Souza-Junior, T. P. (2020). Effect of 16 Weeks of Strength Training and Creatine Supplementation on Strength and Cognition in Older Adults: A Pilot Study. Journal of Exercise Physiology Online, 23(4), 88-94. Scopus.

Stares, A., & Bains, M. (2020). The Additive Effects of Creatine Supplementation and Exercise Training in an Aging Population: A Systematic Review of Randomized Controlled Trials. Journal of Geriatric Physical Therapy, 43(2), 99-112. Scopus. https://doi.org/10.1519/JPT.0000000000000222

Turner, C. E., Byblow, W. D., & Gant, N. (2015). Creatine Supplementation Enhances Corticomotor Excitability and Cognitive Performance during Oxygen Deprivation. JOURNAL OF NEUROSCIENCE, 35(4), 1773-1780. https://doi.org/10.1523/JNEUROSCI.3113-14.2015

Twycross-Lewis, R., Kilduff, L. P., Wang, G., & Pitsiladis, Y. P. (2016). The effects of creatine supplementation on thermoregulation and physical (cognitive) performance: A review and future prospects. Amino Acids, 48(8), 1843-1855. https://doi.org/10.1007/s00726-016-2237-9

Vagnozzi, R., Signoretti, S., Floris, R., Marziali, S., Manara, M., Amorini, A. M., Belli, A., Di Pietro, V., D’Urso, S., Pastore, F. S., Lazzarino, G., & Tavazzi, B. (2013). Decrease in N-Acetylaspartate Following Concussion May Be Coupled to Decrease in Creatine. Journal of Head Trauma Rehabilitation, 28(4), 284-292. https://doi.org/10.1097/HTR.0b013e3182795045

Van Cutsem, J., Roelands, B., Pluym, B., Tassignon, B., Verschueren, J. O., De Pauw, K., & Meeusen, R. (2020). Can creatine combat the mental fatigue-associated decrease in visuomotor skills? Medicine and Science in Sports and Exercise, 52(1), 120-130. Scopus. https://doi.org/10.1249/MSS.0000000000002122

Vieira, I. P., De Paula, A. G., Gentil, P., Pichard, C., Candow, D. G., & Pimentel, G. D. (2020). Effects of Creatine Supplementation on Lower-Limb Muscle Endurance Following an Acute Bout of Aerobic Exercise in Young Men. Sports, 8(2), 12. https://doi.org/10.3390/sports8020012

Watanabe, A., Kato, N., & Kato, T. (2002). Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neuroscience Research, 42(4), 279-285. https://doi.org/10.1016/s0168-0102(02)00007-x

Wyss, M., & Kaddurah-Daouk, R. (2000). Creatine and creatinine metabolism. Physiological Reviews, 80(3), 1107-1213. https://doi.org/10.1152/physrev.2000.80.3.1107

Descargas

Publicado

2023-11-04

Cómo citar

Núñez Núnez, M., Mejía Rubio, A. del R., Pacha Jara, A. G., & Hidalgo Morales, K. P. (2023). Consumo de creatina y cognición: una revisión bibliográfica: Creatine intake and cognition: a literature review. LATAM Revista Latinoamericana De Ciencias Sociales Y Humanidades, 4(5), 122–133. https://doi.org/10.56712/latam.v4i5.1306

Número

Sección

Artículos