Relación y efecto de la historia de descontrol hipertensivo en el trastorno neurocognitivo en pacientes de 60 a 75 años
Relation and effect of the history of hypertensive dyscontrol in neurocognitive disorder in patients aged 60 to 75 years
DOI:
https://doi.org/10.56712/latam.v6i6.5119Palabras clave:
trastorno neurocognitivo, hipertensión arterial sistémica, MMSEResumen
La hipertensión arterial sistémica es el principal factor de riesgo vascular del deterioro neurocognitivo. En consecuencia, el deterioro neurocognitivo está creciendo a un ritmo alarmante en todo el mundo. Determinar la relación y efecto del descontrol hipertensivo en el trastorno neurocognitivo en pacientes de 60 a 75 años. Estudio observacional, analítico y ambispectivo, donde se incluyeron 132 pacientes con HTA, a quienes se les realizó test mini-mental de Folstein en búsqueda de deterioro neurocognitivo. Asimismo, la escala de Lawton y Brody. La población se caracterizó por mujeres de 68.0 años con un nivel de escolaridad de primaria. El 86.4% de ellos tenía un historial de control hipertensivo. Además, el 28.0% de los sujetos tiene algún trastorno neurocognitivo (25.8% leve y 2.3% moderado). En particular, el 41.7% de los pacientes tienen autonomía física. Por último, el 91.9% de ellos se catalogó como probable trastorno neurocognitivo menor según los criterios del DSM-V. Se identificó una correlación negativa moderada y significativa entre el puntaje de MMF y la presión arterial sistólica, lo que indica que mayor deterioro cognitivo se asocia con cifras más altas de presión sistólica, mientras que no se encontró relación con la presión diastólica.
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Boa Sorte Silva, N. C., Petrella, A. F. M., Christopher, N., Marriott, C. F. S., Gill, D. P., Owen, A. M., et al. (2021). The benefits of high-intensity interval training on cognition and blood pressure in older adults with hypertension and subjective cognitive decline: Results from the Heart & Mind Study. Frontiers in Aging Neuroscience, 13, 1–17.
Cai, G., Wang, Y., Chen, R., Xu, S., Luo, J., Sun, Q., et al. (2022). Hypertension status moderated the relationship between the hippocampal subregion of the left GC-ML-DG and cognitive performance in subjective cognitive decline. Disease Markers, 2022.
Clark, L. R., Koscik, R. L., Allison, S. L., Berman, S. E., Norton, D., Carlsson, C. M., et al. (2019). Hypertension and obesity moderate the relationship between β‐amyloid and cognitive decline in midlife. Alzheimer’s & Dementia, 15(3), 418–428. https://doi.org/10.1016/j.jalz.2018.09.008
Zúñiga-Salazar, G. A., Hincapié-Arias, S. M., Salazar-Bolaños, E. E., Lara-Terán, J. J., Cáceres-Vinueza, S. V., & Duarte-Vera, Y. C. (2020). Impact of arterial hypertension on the cognitive function of patients between 45 and 65 years. Archivos de Cardiología de México, 90(3).
Santisteban, M. M., & Iadecola, C. (2018). Hypertension, dietary salt and cognitive impairment. Journal of Cerebral Blood Flow & Metabolism, 38(12), 2112–2128.
Ungvari, Z., Toth, P., Tarantini, S., Prodan, C. I., Sorond, F., Merkely, B., et al. (2021). Hypertension-induced cognitive impairment: From pathophysiology to public health. Nature Reviews Nephrology, 17(10), 639–654. https://doi.org/10.1038/s41581-021-00430-6
Liu, Y., Dong, Y. H., Lyu, P. Y., Chen, W. H., & Li, R. (2018). Hypertension-induced cerebral small vessel disease leading to cognitive impairment. Chinese Medical Journal, 131(5), 615–619.
Wei, J., Yin, X., Liu, Q., Tan, L., & Jia, C. (2018). Association between hypertension and cognitive function: A cross-sectional study in people over 45 years old in China. Journal of Clinical Hypertension, 20(11), 1575–1583.
Zhuo, X., Huang, M., Wu, M., & Elshmaa, M. (2022). Analysis of cognitive dysfunction and its risk factors in patients with hypertension. Medicine, 101(10), e28934.
Mansukhani, M. P., Kolla, B. P., & Somers, V. K. (2019). Hypertension and cognitive decline: Implications of obstructive sleep apnea. Frontiers in Cardiovascular Medicine, 6, 1–9.
Wan, C., Zong, R. Y., & Chen, X. S. (2022). The new mechanism of cognitive decline induced by hypertension: High homocysteine-mediated aberrant DNA methylation. Frontiers in Cardiovascular Medicine, 9, 1–12.
Streit, S., Poortvliet, R. K. E., Den Elzen, W. P. J., Blom, J. W., & Gussekloo, J. (2019). Systolic blood pressure and cognitive decline in older adults with hypertension. Annals of Family Medicine, 17(2), 100–107.
Naing, H. L., & Teo, S. P. (2020). Impact of hypertension on cognitive decline and dementia. Annals of Geriatric Medicine and Research, 24(1), 15–19.
Iadecola, C., & Gottesman, R. F. (2019). Neurovascular and cognitive dysfunction in hypertension. Circulation Research, 124(7), 1025–1044.
Levine, D. A., Springer, M. V., & Brodtmann, A. (2022). Blood pressure and vascular cognitive impairment. Stroke, 53(4), 1104–1113.
Haring, B., Wu, C., Coker, L. H., Seth, A., Snetselaar, L., Manson, J. E., et al. (2016). Hypertension, dietary sodium, and cognitive decline: Results from the Women’s Health Initiative Memory Study. American Journal of Hypertension, 29(2), 202–216.
Huang, Y., Zheng, H., Tan, K., Sun, X., Ye, J., & Zhang, Y. (2020). Circulating metabolomics profiling reveals novel pathways associated with cognitive decline in patients with hypertension. Therapeutic Advances in Neurological Disorders, 13, 1–13. https://doi.org/10.1177/1756286420947973
Wiesmann, M., Zerbi, V., Jansen, D., Lütjohann, D., Veltien, A., Heerschap, A., et al. (2017). Hypertension, cerebrovascular impairment, and cognitive decline in aged AβPP/PS1 mice. Theranostics, 7(5), 1277–1289.
Kerkhofs, D., Van Hagen, B. T., Milanova, I. V., Schell, K. J., Van Essen, H., Wijnands, E., et al. (2020). Pharmacological depletion of microglia and perivascular macrophages prevents vascular cognitive impairment in Ang II-induced hypertension. Theranostics, 10(21), 9512–9527.
Miller, K. B., Miller, V. M., & Barnes, J. N. (2019). Pregnancy history, hypertension, and cognitive impairment in postmenopausal women. Current Hypertension Reports, 21(12).
Hay, M., Barnes, C., Huentelman, M., Brinton, R., & Ryan, L. (2020). Hypertension and age-related cognitive impairment: Common risk factors and a role for precision aging. Current Hypertension Reports, 22(10).
Gupta, A., Perdomo, S., Billinger, S., Beddhu, S., Burns, J., & Gronseth, G. (2020). Treatment of hypertension reduces cognitive decline in older adults: A systematic review and meta-analysis. BMJ Open, 10(11).
Ma, Y., Hua, R., Yang, Z., Zhong, B., Yan, L., & Xie, W. (2021). Different hypertension thresholds and cognitive decline: A pooled analysis of three ageing cohorts. BMC Medicine, 19(1), 1–13.
Kujovic, M., Lipka, T., Zalman, M., Baumann, L., Jänner, M., & Baumann, B. (2023). Treatment of hypertension and obstructive sleep apnea counteracts cognitive decline in common neurocognitive disorders in diagnosis-related patterns. Scientific Reports, 13(1), 1–19. https://doi.org/10.1038/s41598-023-33701-2
Militaru, M., Rachieru, C., Lighezan, D. F., & Militaru, A. G. (2021). The impact of hypertension and atrial fibrillation on cognitive decline and subclinical atherosclerosis. Brain Sciences, 11(6).
Tadic, M., Cuspidi, C., & Hering, D. (2016). Hypertension and cognitive dysfunction in the elderly: Blood pressure management for this global burden. BMC Cardiovascular Disorders, 16(1), 1–9. https://doi.org/10.1186/s12872-016-0386-0
Xu, Y., Bouliotis, G., Beckett, N. S., Antikainen, R. L., Anderson, C. S., Bulpitt, C. J., et al. (2022). Left ventricular hypertrophy and incident cognitive decline in older adults with hypertension. Journal of Human Hypertension.
Xu, T., Ye, X., Lu, X., Lan, G., Xie, M., Huang, Z., et al. (2023). Association between solid cooking fuel and cognitive decline: Three nationwide cohort studies in middle-aged and older population. Environment International, 173, 107803.
Mone, P., Pansini, A., Frullone, S., & De Donato, A. (2020). COVID-19 resource centre information overview. Elsevier Connect. (Nota: Referencia incompleta en el original).
Tapia, A. I. D. (2024). Asociación entre control de hipertensión arterial sistémica y deterioro cognitivo en adultos de 50 a 75 años (Tesis de especialidad). Instituto Mexicano del Seguro Social. https://www.researchgate.net/publication/388289195_Asociacion_entre_Control_de_Hipertension_Arterial_Sistemica_y_Deterioro_Cognitivo_en_Adultos_de_50_a_75_Anos
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Derechos de autor 2025 Juan Eduardo Galvez Escalante, Deisy Cecilia Rivera Angles, Herenia del Carmen Padrón Sánchez
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
